Novel Regulators of Inflammatory Arthritis and Bone Erosion

R01AR066551 (Faccio)

NIH/NIAMS $392,753 Total

The goal of this study is to examine M1 macrophage inflammatory reactions through calcium signaling in systemic Juvenile arthritis.

Role of TMEM178 in Macrophage Activation and Bone Erosion in Inflammatory Arthritis

Shriners Hospitals for Children (Faccio)

Project # 85100
$250,000 Total Annual Support

The goal of this study is to examine mechanisms of macrophage activation and osteoclast functions using models of arthritis.

Osteogenic and Angiogenic Response to Skeletal Loading

R01 AR050211 (Silva)

$418,428 Total Annual Support

The Project Goals are to determine the mechano-biological pathways that lead to bone formation after mechanical loading.

Role of Mitochondrial Dynamics in Bone Homeostasis

R01 AR070030-01A1 (Novack)

$1,430,325 Total Project Support

The goal of this project is to establish the role of mitochondrial dynamics in the function of osteoclasts and osteoblasts and thereby in the maintenance of bone mass and strength with age.

Targeting the Bone Stromal Compartment to Enhance Tumor Cell Killing and Protect Against Chemotherapy-induced Bone Loss

BC151402 (Stewart)

$250,000 Total Annual Support

Goal is to determine how senescence associated secretory phenotype (SASP) factors contribute to bone loss following chemotherapy and elucidate the mechanisms by which SASP create a protective niche within the bone.

Characterization and Tumorigenic Action of Osteolineage Cells in the Breast Cancer Microenvironment

Multi-PI Pre-R01 (Faccio/Civitelli)

Siteman Investment Program
$200,000 Total Annual Support

The long-term goals of this new project are to define new mechanisms by which tumor and stromal osteolineage cells affect each other to favor tumor progression and metastasis at extraskeletal sites. Ultimately, this work will lead to the discovery of new markers of tumor progression and the development of new therapeutic strategies aimed at interrupting environmental support to cancer growth and metastasis.

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