Epigenetic Regulation in Cartilage Tissue
R01AR069605 (PI’s: O’Keefe & McAlinden)
The goals of this program are to elucidate novel epigenetic-regulated pathways in chondrocytes and to identify new targets to control cartilage homeostasis.
Resource Based Center for Musculoskeletal Biology and Medicine
Our goal is to advance current knowledge to bridge gaps in our understanding of the cellular, molecular and functional basis of joint arthritis, and to develop and evaluate new therapeutic strategies.
Role: Associate Project Lead, Resource Core D
Epigenetic Regulation of Bone Regeneration in Inflammatory Disease
NIH/NIAMS $338,262 direct costs
The main goal of this study is to define Dnmt3b-mediated molecular and epigenetic changes to further elucidate a novel pathway in fracture repair.
Barnes-Jewish Hospital Foundation $8,999
The goal of this funding is to support the International Microsurgical Training Fellowship.
Epigenetic Regulation of Chondrogenesis and Cartilage Development
1K99AR075899-01 (Wu, Chia-Lung)
NIH/NIAMS $83,424/$914,571 direct costs
The overall goals of this study are to determine the function and mechanism of PRDM16, a histone methyltransferase, in regulating chondrocyte specification and cartilage development using human induced pluripotent stem cells and cartilage-specific conditional knock-out mouse models. An in-depth understanding of the epigenetic regulation of chondrogenesis and limb development could provide important insights into the development and homeostasis of cartilage, as well as the refinement of new strategies for cartilage repair and regeneration.