Epigenetic Regulation in Cartilage Tissue
R01AR069605 (PI’s: O’Keefe & McAlinden)
04/01/2016-03/31/2021
NIH/NIAMS $250,000
The goals of this program are to elucidate novel epigenetic-regulated pathways in chondrocytes and to identify new targets to control cartilage homeostasis.
Resource Based Center for Musculoskeletal Biology and Medicine
P30AR074992-01 (Silva)
04/12/2019-03/31/2024
NIH/NIAMS $500,000
Our goal is to advance current knowledge to bridge gaps in our understanding of the cellular, molecular and functional basis of joint arthritis, and to develop and evaluate new therapeutic strategies.
Role: Associate Project Lead, Resource Core D
Epigenetic Regulation of Bone Regeneration in Inflammatory Disease
1R01AR075860-01 (Shen)
07/08/2019-06/30/2024
NIH/NIAMS $338,262 direct costs
The main goal of this study is to define Dnmt3b-mediated molecular and epigenetic changes to further elucidate a novel pathway in fracture repair.
Role: Co-Investigator
Orthopedic Education
4511
07/01/2018-06/30/2020
Barnes-Jewish Hospital Foundation $8,999
The goal of this funding is to support the International Microsurgical Training Fellowship.
Role: PI
Epigenetic Regulation of Chondrogenesis and Cartilage Development
1K99AR075899-01 (Wu, Chia-Lung)
08/07/2019-07/31/2024
NIH/NIAMS $83,424/$914,571 direct costs
The overall goals of this study are to determine the function and mechanism of PRDM16, a histone methyltransferase, in regulating chondrocyte specification and cartilage development using human induced pluripotent stem cells and cartilage-specific conditional knock-out mouse models. An in-depth understanding of the epigenetic regulation of chondrogenesis and limb development could provide important insights into the development and homeostasis of cartilage, as well as the refinement of new strategies for cartilage repair and regeneration.
Role: Mentor
