Resource Based Center for Musculoskeletal Biology and Medicine
04/17/2019 – 3/31/2024
(Core A and B) ADC
Director of the Center and directs Core B, which supports evaluation of musculoskeletal structure and strength in mouse models.
Response of the Osteoporotic Skeleton to in Vivo Loading
R01 AR047867 (Silva)
07/13/2001 – 03/31/2022
NIH/NIAMS $262,682 ADC
Assess the responsiveness of the osteoporotic skeleton to increased mechanical loading using mouse models of aging, with focus on the roles of osteoblast recruitment and Wnt signaling.
Osteogenic and Angiogenic Response to Skeletal Loading
R01 AR050211 (Silva)
07/25/2003 – 02/29/2020
NIH/NIAMS $246,941 ADC
Our goal is to determine the mechanobiological pathways that lead to bone formation after mechanical loading.
Rotator Cuff Degeneration and Repair
R01 AR057836 (Thomopoulos S and Galatz LM)
09/15/2010 – 08/31/2021
NIH/NIAMS $103,780 ADC
The goal of this project is to determine the mechanisms of rotator cuff degeneration and the effects of degeneration on tendon-to-bone healing.
Role: Subaward PI
The Role of Physiologic And Pathologic Ages On Rage Signaling In IVD Degeneration
R01 AR074441-01A1 (Tang)
NIH/NIAMS $220,000 ADC
Investigate the role of signaling of the AGE-RAGE axis in intervertebral disc homeostasis, injury, and disease. Goals are to investigate the role of signaling of the AGE-RAGE axis in intervertebral disc homeostasis, injury, and disease.
The Development and Rescue of an Atrophic Nonunion Model
F32 AR07619101 (Hixon)
09/01/2019 – 05/31/2022
NIH/NIAMS $63,926 ADC
This project will investigate the 3.6Col1-tk (Col1-tk) mouse as a model of atrophic nonunion, a form of nonunion where an osteochondral callus fails to form, making it extremely challenging to treat. The goal of this project is to establish a more relevant, pre-clinical nonunion model to test therapeutic interventions and develop a novel tissue-engineered scaffold to restore bone union.
Cellular and Molecular Mechanisms of Murine Digit Regeneration
F32 AR074895 (Qu)
02/01/2019 – 01/31/2021
NIH/NIAMS $63,926 ADC
This project will investigate the spatiotemporal response of PCs after digit amputation using Osx-CreERT2;Ai9 inducible reporter transgenic mice and test the requirement of proliferating PCs during digit regeneration by inducible conditional ablation of replicating PCs using 3.6Col1a1-tk transgenic mice.
Restoring the Responsiveness of Aged Bone to Mechanical Loading
F30 AG066310 (Chermside-Scabbo)
9/16/2019 – 9/15/2022
NIH/NIA $30,942 ADC
The focus of this project is to test mechanistically-motivated strategies to restore the responsiveness of aged bone to mechanical loading and to identify additional pathways that can promote bone formation in aged bone and reduce osteoporotic fracture risk.
Skeletal Disorders Training Program
T32 AR060719 (Civitelli)
05/01/2011 – 04/30/2021
NIH/NIAMS $329,766 ADC
This training program educates and forms the next generation of scientists and physicians committed to skeletal disorders, so that research in this area can be perpetuated, a better understanding of the causes of these diseases can be achieved, and the search for new treatment modalities can progress.
Role: Associate Director
The Role of YAP and TAZ Transcriptional Coactivators in Osteoblast Lineage Cells
5 P20 GM125503-02
2/16/2018 – 1/31/2023
NIH/NIGMS $298,902 ADC
Role: Mentor – Project 8231 (Xiong)