The Role of Lactate in Intervertebral Disc Degeneration
AO North America/AONA (Goodwin)
Intervertebral disc degeneration has been shown to progress in models blocking glucose importation, lactate exportation, and disc-injury. Prior work has demonstrated at least some reliance on increasing intracellular lactate for this degeneration. These studies seek to define the role of lactate and lactate transport in intervertebral disc degeneration.
Novel Targeting of Osteosarcoma via Lactate Transport Inhibition
Children’s Discovery Institute/CDI (Goodwin)
The purpose of this project is to not only gather preliminary data in preparation for an R01, but also to generate critical preclinical data on which to base clinical trials utilizing lactate transporter inhibition.