Epigenetic Regulation in Cartilage Tissue
R01 AR069605 (Regis O’Keefe)
The goals of this project are to determine the functional roles of the epigenetic de novo DNA methyltransferase enzyme, Dnmt3b, in regulating post-natal articular cartilage homeostasis.
Resource Based Center for Musculoskeletal Biology and Medicine
P30 AR074992 (Matthew Silva)
Our goal is to advance current knowledge to bridge gaps in our understanding of the cellular, molecular and functional basis of joint arthritis, and to develop and evaluate new therapeutic strategies.
Role: Associate Director, Resource Core D
Epigenetic Regulation of Bone Regeneration in Inflammatory Disease
R01 AR075860 (Jie Shen)
The goal of this study is to determine the functional role of the epigenetic DNA methylation enzyme, Dnmt3b, and its molecular regulation of Rbpj, in mesenchymal progenitor cells and chondrocytes during normal and inflammatory conditions (abnormal) fracture repair.