Epigenetic Regulation in Cartilage Tissue

R01 AR069605 (Regis O’Keefe)

NIH/NIAMS $220,000

The goals of this project are to determine the functional roles of the epigenetic de novo DNA methyltransferase enzyme, Dnmt3b, in regulating post-natal articular cartilage homeostasis.
Role: Co-Investigator

Resource Based Center for Musculoskeletal Biology and Medicine

P30 AR074992 (Matthew Silva)

NIH/NIAMS $500,000

Our goal is to advance current knowledge to bridge gaps in our understanding of the cellular, molecular and functional basis of joint arthritis, and to develop and evaluate new therapeutic strategies.
Role: Associate Director, Resource Core D

Epigenetic Regulation of Bone Regeneration in Inflammatory Disease

R01 AR075860 (Jie Shen)

NIH/NIAMS $338,262

The goal of this study is to determine the functional role of the epigenetic DNA methylation enzyme, Dnmt3b, and its molecular regulation of Rbpj, in mesenchymal progenitor cells and chondrocytes during normal and inflammatory conditions (abnormal) fracture repair.
Role: PI

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