Cartilage Repair with Mesenchymal Stem Cells (MSCs) Delivered in a Novel Chondroitin Sulfate/Polyethylene Glycol Hydrogel in an Equine Animal Model

OA-2016-1 (Pascual-Garrido)

AOSSM/Sanofi $50,000

The goal of this study is to assess cartilage healing in an equine animal model with MSCs delivered in a novel hydrogel.

Post-Market Data Collection for Biologically Assisted Core Decompression of the Femoroacetabular Head Using the PerFuse Instrument and BioCUE

REGP-44-00 (Pascual-Garrido)

Zimmer-Biomet $250,000

The aim of this study is to evaluate clinical outcomes in patients with avascular necrosis of the femoral head treated with BMAC and PRP delivered in a novel biologically assisted core decompression technique.

Intraarticular Metabolic Activity in the Pre-Osteoarthritic Hip

18-003 (Pascual-Garrido)

OREF $50,000

The purpose of the proposed project is to study the metabolic activity in the pre-OA joint, specifically the pre-OA hip. Hip dysplasia and hip FAI are true natural models of pre-OA. Pre-OA represents the long transition from normal, healthy cartilage to osteoarthritic cartilage. Identifying the specific molecular pathways that initiate joint degeneration may open a broad spectrum for a potential future application of diagnostic tools and interventional disease modifying OA drugs (DMOAD) for the treatment of pre-OA and secondary OA.

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