Novel Regulators of Inflammatory Arthritis and Bone Erosion
R01AR066551 (Faccio)
04/13/2015-03/31/2021
NIH/NIAMS $392,753 Total
The goal of this study is to examine M1 macrophage inflammatory reactions through calcium signaling in systemic Juvenile arthritis.
Role of TMEM178 in Macrophage Activation and Bone Erosion in Inflammatory Arthritis
Shriners Hospitals for Children (Faccio)
01/01/2015-12/31/2019
Project # 85100
$250,000 Total Annual Support
The goal of this study is to examine mechanisms of macrophage activation and osteoclast functions using models of arthritis.
Osteogenic and Angiogenic Response to Skeletal Loading
R01 AR050211 (Silva)
07/25/2003-02/28/2021
NIH/NIAMS
$418,428 Total Annual Support
The Project Goals are to determine the mechano-biological pathways that lead to bone formation after mechanical loading.
Role of Mitochondrial Dynamics in Bone Homeostasis
R01 AR070030-01A1 (Novack)
07/01/2016–06/30/2021
NIH/NIAMS
$1,430,325 Total Project Support
The goal of this project is to establish the role of mitochondrial dynamics in the function of osteoclasts and osteoblasts and thereby in the maintenance of bone mass and strength with age.
Targeting the Bone Stromal Compartment to Enhance Tumor Cell Killing and Protect Against Chemotherapy-induced Bone Loss
BC151402 (Stewart)
09/30/2016-09/29/2019
DoD-CDMRP
$250,000 Total Annual Support
Goal is to determine how senescence associated secretory phenotype (SASP) factors contribute to bone loss following chemotherapy and elucidate the mechanisms by which SASP create a protective niche within the bone.
Characterization and Tumorigenic Action of Osteolineage Cells in the Breast Cancer Microenvironment
Multi-PI Pre-R01 (Faccio/Civitelli)
07/01/2017–06/30/2020
Siteman Investment Program
$200,000 Total Annual Support
The long-term goals of this new project are to define new mechanisms by which tumor and stromal osteolineage cells affect each other to favor tumor progression and metastasis at extraskeletal sites. Ultimately, this work will lead to the discovery of new markers of tumor progression and the development of new therapeutic strategies aimed at interrupting environmental support to cancer growth and metastasis.
