Regulation of Chondrogenesis by Long Non-Coding RNAs
R21 AR072193-01A1 (PI: McAlinden)
04/01/2018 – 02/28/2022
NIH/NIAMS $110,000 ADC
The goals of this study are to determine the function and mechanism of specific lncRNAs in regulating early commitment of progenitor cells toward the chondrocyte lineage.
Epigenetic Regulation in Cartilage Tissue
R01 AR069605 (Contact PI: O’Keefe, MPI: McAlinden)
03/01/2016 – 02/28/2022
NIH/NIAMS $220,000 ADC
The goals of this project are to determine the functions of the DNA methylation enzyme, Dnmt3b, in regulating post-natal articular cartilage homeostasis.
Targeting MicroRNAs for Osteochondral Tissue Engineering
R21 AR077203 (PI: McAlinden)
04/01/2020 – 03/31/2022
NIH/NIAMS $150,000 ADC
The goal of this project is to attempt to generate human native-like osteochondral tissue by seeding microRNA-transduced cartilage progenitor cells into 3D woven PCL scaffolds.
MicroRNA Regulation of Bone Formation and Repair
R01 AR075730-01A1 (PI: McAlinden)
04/01/2020 – 03/31/2025
NIH/NIAMS $340,000 ADC
The goals of this project are to elucidate the function and mechanism of specific microRNAs on: i) in vitro osteogenesis; ii) in vivo bone repair processes in established mouse models of bone fracture and iii) heterotopic ossification formation in a clinically relevant mouse model.